第 4 季 共 22 集
播出时间：2008年9月2日
第 1 集 Scylla
播出时间：2008年9月2日
Michael has trailed Gretchen/Susan, Whistler and Mahone to L.A. Chaos reigns in SONA while T-Bag, Bellick and Sucre go missing. Lincoln and L.J. continue to stay with Sofia.
第 2 集 Breaking And Entering
播出时间：2008年9月2日
"Breaking & Entering" is the 59th episode of the American television series Prison Break and was shown together with the first episode of its fourth season as a two-hour episode with "Scylla". It was broadcast on September 1, 2008 in the United States on the Fox Network.
第 3 集 Shut Down
播出时间：2008年9月9日
Michael attempts to track the cardholder and avoid going back to prison. Wyatt finds new information regarding Sara's whereabouts. Elsewhere, T-Bag uses a new identity to make a new life for himself.
第 4 集 Eagles and Angels
播出时间：2008年9月16日
Michael, Lincoln and Sucre must crash a police benefit to obtain the next card key. Reeling from another death, Sarah falls back into an old habit. T-Bag arouses suspicion and runs into some old “friends” his first day on the job.
第 5 集 Safe and Sound
播出时间：2008年9月23日
Self locates another card hidden in a safe within a secure federal building, as Mahone continues his quest for revenge. Meanwhile, T-Bag's new life may be in jeopardy.
第 6 集 Blow Out
播出时间：2008年9月30日
The entire operation may be in jeopardy when Mahone gets into trouble with the law. Gretchen's sister receives a surprise visitor. The Company may be onto Self. T-Bag continues to raise suspicions at Gate.
第 7 集 Five the Hard Way
播出时间：2008年10月7日
Lincoln takes members of the team to Las Vegas where Sucre gets an indecent proposal. Sarah learns about Michael’s condition, and Roland pushes his luck too far. Gretchen teams up with T-Bag who makes an offer to Michael he cannot refuse. Meanwhile, the secrets in Whistler’s bird book are finally revealed.
第 8 集 The Price
播出时间：2008年10月21日
Lincoln works to retrieve the final card, which is being held by the General. Michael and Self are forced to work with Gretchen. Meanwhile, Roland continues to be berated for losing the transcribing device in Las Vegas.
第 9 集 Greatness Achieved
播出时间：2008年11月4日
Wyatt gets a taste of his own medicine, and Mahone finds some resolution. T-Bag scrambles when the police investigate his missing co-worker while Gretchen gets cozy with a Company man. Meanwhile, Michael’s condition continues to worsen, and a team member makes the ultimate sacrifice while planning the underground break-in for Scylla.
第 10 集 The Legend
播出时间：2008年11月11日
Sara is left with no choice but to take Michael to the hospital as his condtion rapidly worsens. Sucre and Lincoln are faced with unknown territory as they are left in charge of the operation. Elsewhere, agent Self makes a surprising ally.
第 11 集 Quiet Riot
播出时间：2008年11月18日
Michael races against time and his ailing health to break into the Company headquarters to steal Scylla, but the break-in’s success lies with Sucre. Gretchen dresses up for a meeting with the General and one final attempt to get the last card key. T-Bag must make a decision to leave his criminal ways for good.
第 12 集 Selfless
播出时间：2008年11月25日
Sara takes a hostage in a bid to secure Scylla. In the meantime, Michael and Lincoln finally meet the General while one of their members switches allegiance.
第 13 集 Deal Or No Deal
播出时间：2008年12月2日
It's up to Michael to hold the gang together after they find out they were betrayed by one of their own. Meanwhile, Gretchen is blackmailed by T-Bag's new partner.
第 14 集 Just Business
播出时间：2008年12月9日
Michael, whose condition is deteriorating, winds up in the hands of The Company who promise Lincoln that they can save Michael's life in exchange for a favor. Elsewhere, Gretchen and Self wind up with Scylla and a buyer.
第 15 集 Going Under
播出时间：2008年12月16日
Michael gets medical attention from the most unlikely of places, and Charles Westmoreland returns to help uncover the true meaning of Scylla. Meanwhile, Lincoln and Sucre race to stop Gretchen before Scylla is lost forever.
第 16 集 The Sunshine State
播出时间：2008年12月23日
Lincoln and his new partners arrive in Miami to recover Scylla from its shocking new owner, and Sara searches for a missing Michael who learns some surprising information about his past. Meanwhile, a double-crossing leads to a death and an arrest in "The Sunshine State."
第 17 集 The Mother Lode
播出时间：2009年4月18日
Michael and Sara journey to Miami while Lincoln meets with his mother.<br />
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T-Bag and Self's mission to locate Scylla takes a dramatic turn.<br />
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The General comes under pressure.
第 18 集 VS.
播出时间：2009年4月25日
Michael and Lincoln come to blows over Scylla as Christina sets the wheels in motion for her plan. Meanwhile, Sara receives life-changing news. T-Bag arrives at the Indian Embassy. The General becomes increasingly paranoid.
第 19 集 S.O.B.
播出时间：2009年5月2日
Michael's reunion with Christina is soured when she drops a bombshell regarding Lincoln, and T-Bag grows determined to prove he is worthy of being a member of the Company.
第 20 集 Cowboys and Indians
播出时间：2009年5月9日
Pandemonium erupts at the hotel following the assassination, and Christina puts the final pieces of her plan together. Meanwhile, the General makes good on his threat, and Michael is forced to choose between saving either Lincoln or Sara.
第 21 集 Rate of Exchange
播出时间：2009年5月16日
Familiar faces return to help Michael end his quest to bring down The Company once and for all.
第 22 集 Killing Your Number
播出时间：2009年5月16日
Michael tries to bring down the Company once and for all.
