第 4 季 共 13 集
播出时间：2008年9月19日
第 1 集 Mac and Dennis: Manhunters
播出时间：2008年9月19日
Charlie and Dee have been stealing Frank's delicious meats, so Frank leaves out human meat to get back at them. Driven by their cannibalistic needs, Charlie and Dee go in search of human flesh. Mac and Dennis harass Frank for hunting defenseless animals and think it would be much more badass to hunt something that could fight back ... like a human.
第 2 集 The Gang Solves the Gas Crisis
播出时间：2008年9月19日
Charlie, Mac, and Dennis formulate a plan to take advantage of the rising gas prices. By purchasing excess amounts now, they can sell it in the future and profit. As usual, things don't go as planned. Dee is also out to make money when she learns that Bruce is going to give the family fortune to a Muslim cultural center. She and Frank try to stop him and get the cash for themselves.
第 3 集 America’s Next Top Paddy’s Billboard Model Contest
播出时间：2008年9月26日
Due to the gang's latest "business expenses," Paddy's is in dire need of money. Frank buys a billboard to advertise the bar, but Dee decides to create a viral video to post on YouTube for promotion. Charlie quickly joins her, leaving Frank and Mac to hold a contest for some hot models to feature on the billboard. Naturally, Dennis joins the competition to prove his worth.
第 4 集 Mac’s Banging the Waitress
播出时间：2008年9月26日
Charlie finds out that the waitress has been seeing someone. He calls on Mac, his so-called best friend, to find out more information about the guy and to beat him up. However, it turns out that Mac is the guy the waitress has supposedly been seeing. Dennis, heartbroken that he's not Charlie's best friend, tries to win him over.
第 5 集 Mac and Charlie Die (1)
播出时间：2008年10月3日
Part 1 of 2. Mac and Charlie fake their deaths to avoid the wrath of Mac's father who was released from prison and is out for vengeance.
第 6 集 Mac and Charlie Die (2)
播出时间：2008年10月3日
Part 2 of 2. Dennis, Frank, and Dee find unique ways of coping with the apparent loss of their friends.
第 7 集 Who Pooped the Bed?
播出时间：2008年10月10日
Charlie and Frank awake to find poop in their bed. Neither will confess to being the owner, so they, Mac, and Dennis try to scientifically deduce who dropped the deuce. Dee wants to do something a bit more sophisticated, so she invites the waitress and Artemis to a girls' night out.
第 8 集 Paddy’s Pub: The Worst Bar in Philadelphia
播出时间：2008年10月17日
A newspaper critic is kidnapped by the gang after he calls Paddy's pub the worst bar in Philadelphia.
第 9 集 Dennis Reynolds: An Erotic Life
播出时间：2008年10月24日
After discovering Dennis' erotic memoir, Mac and Frank attempt to make some money off of it. Meanwhile, Dee and Charlie decide to spend a day in each other's shoes.
第 10 集 Sweet Dee Has a Heart Attack
播出时间：2008年10月31日
After Dee suffers a heart attack, she and Dennis try to live a healthier lifestyle. Meanwhile, Charlie and Mac take corporate jobs to get health insurance.
第 11 集 The Gang Cracks the Liberty Bell
播出时间：2008年11月7日
The gang fudge history by claiming that Paddy's Pub was responsible for cracking the Liberty Bell in an attempt to turn their dive into a Philadelphia landmark.
第 12 集 The Gang Gets Extreme: Home Makeover Edition
播出时间：2008年11月14日
Hoping to make their own dreams come true, the gang sets out to give an unexpected family an extreme home makeover.
第 13 集 The Nightman Cometh
播出时间：2008年11月21日
In the season finale, Charlie gets the gang to help him put together a rock opera based on his song "Nightman."
