Drifting from fiction to documentary, Greatest Hits tells the story of Emilio, a man in his fifties who shows up at the family home after fifteen years of absence. His wife and his twenty-eight year old son receive him with bitterness and confusion. After a couple of days they decide to kick him out, only to find out that he has left on his own accord. The son ends up tracking down Emilio and spends a couple of days hanging out with him in his apartment.