Go With Your Gut is a documentary on the theme of always following one's heart. It tells the stories of seven Chinese independent domestic-brand founders: Mao Jihong, founder of Liwai clothing and the lifestyle brand Fang Suo; Zhuang Song Lie, founder of Sculpting in Time Café; Qian Xiaohua, founder of Librairie Avant-Garde Bookstore; Wu Yonghong, founder of SoLife Home; Ba Wenhan, founder of Ba Wenhan Online Food Store; Zhang Qiang, founder of Dr. Smile Medical Group; and Tina, founder of The Banff Film Festival (China). With a sense of dedication to their careers, these ordinary people walk the entrepreneurial path towards achieving their dreams. Some of them have already found success, such as Mao Jihong with his business model for a lifestyle brand, and Tina, who has been promoting extreme-sports films for five years. However, Zhuang Song Lie is still searching for freedom and self-fulfillment after 20 years of hard work. Ba Wenhan went to the countryside after graduating from university to become an entrepreneur. Although he does not know the future of the physical bookstore, he opened one in a rural area of Anhui province. Meanwhile, medical pioneer Zhang Qiang deals with questions from colleagues and investors. They all remain humble and encounter various difficulties. In every situation they always follow their guts, knowing that they will only live once and refusing to settle for a mediocre exist.