第 4 季 共 15 集
播出时间：2022年3月11日
第 1 集 PLAIN SLICE
播出时间：2022年3月11日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Plus, correspondents Rainey and Tawanda see whether Desus & Mero can tell if strangers on the street are really from New York. Illustrious guest: Denzel Washington. Season premiere.
第 2 集 IT'S GONNA HIT
播出时间：2022年3月25日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Plus, Desus & Mero take a look at the world of modern art, roasting some non-fungible tokens (NFTs) and trying to guess how much money they've been sold for. Illustrious guests: Tom Holland and Mark Wahlberg.
第 3 集 GRAB YOUR BAGS
播出时间：2022年4月1日
Desus Nice and The Kid Mero go in on the news and cultural stories of the past week. In search of even more hardware for their award-winning television show, Desus & Mero enlist American Cornhole League pro Lori Dool to help turn them into champions. After an intense training session, they take on a team of ringers from Long Island. Will Desus & Mero pull off the upset and add a new trophy to their shelf? Illustrious guest: Samuel L. Jackson.
第 4 集 THAT'S BRIOCHE
播出时间：2022年4月8日
Desus Nice and The Kid Mero go in on the news and cultural stories of the past week. Then, in the wake of rap star Pusha T's recent fast food endorsement, Desus & Mero conduct a blind taste test to find the best fish sandwich on the market. It's a test of both the sandwiches' flavor and the hosts' stomachs' endurance. Illustrious guest: Pusha T.
第 5 集 BIG HATER ENERGY
播出时间：2022年4月15日
Desus Nice and The Kid Mero go in on the news and cultural stories of the past week. Then, the two hosts are tested on their knowledge of reality dating show stars. Can they distinguish a contestant who is "too hot to handle" from one who got married at first sight? Either way, the brand is strong and it's here for the right reasons. Illustrious guest: Michelle Yeoh.
第 6 集 LUCITE SITUATION
播出时间：2022年4月22日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Then, with the help of Karleen Roy, event planner to the stars, Desus & Mero prepare to throw Rihanna the greatest baby shower of all time. She has no idea that this event is in the works, but Desus & Mero hope that by planning an incredible party, they can get her to show up. Illustrious guest: Damson Idris.
第 7 集 CHEATER BELLY
播出时间：2022年4月29日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Plus, correspondents Rainey and Tawanda ask people on the street if they've ever cheated on their partners and then see if Desus & Mero can spot the cheaters - some of whom share wild stories. Illustrious guest: Earl Sweatshirt.
第 8 集 BAD BILLS
播出时间：2022年5月6日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Plus, John Wilson (How To With John Wilson) joins Desus & Mero at a local junk store to pick out some new decor for their offices. Wilson is an expert at finding beauty in unexpected places, and he helps Desus & Mero find the most precious treasure of all: friendship. Illustrious guest: Jon Bernthal.
第 9 集 RUM ON THEIR GUMS
播出时间：2022年5月13日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Plus, Desus & Mero are inspired by a Bay Area kindergarten class's pep talk hotline to create a phone line of their own. They enlist some New York City kids to record discouraging messages for grownups, and Abbott Elementary star Janelle James stops by to help out.
第 10 集 IT'S A PARTY NOW
播出时间：2022年5月20日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Then, Desus & Mero throw the surprise baby shower they've been organizing for Rihanna with the help of celebrity event planner Karleen Roy. Celebrity attendees include CBS News legend Maurice DuBois. The decorations are spectacular and the places are set at the banquet table...but will Rihanna make an appearance? Illustrious guest: Quinta Brunson.
第 11 集 BOTTLES, BOTTLES, BOTTLES
播出时间：2022年5月27日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Then, Kenan Thompson from Saturday Night Live joins Desus & Mero to taste test several brands of bottled water, including one that costs over $1,000. They'll see if they can tell whether they're sipping pricey imported spring water or plain old New York City tap water. Can Desus, Mero and Kenan guess how much each bottle costs by the taste or is it all just...water to them?
第 12 集 AUTO-CLAPPING
播出时间：2022年6月3日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Then, Desus & Mero take a look at some of the most lavish celebrity homes currently for sale and try to guess who they belong to. Will the decor provide enough information for them to correctly identify the sellers? Illustrious guest: Sam Jay.
第 13 集 SAY NO TO THE MUSTACHE
播出时间：2022年6月10日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Plus, in a new segment called "What's Your Damage?" correspondent Heben Nigatu opens an amateur therapist's office in a New York City park to find out what is wrong with the men of NYC. Desus and Mero try to guess what each guy's big problem is. Illustrious guest: Wanda Sykes.
第 14 集 SCIENCE AND FELONIES
播出时间：2022年6月17日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Then, Seth Meyers (of NBC's Late Night with Seth Meyers) joins Desus & Mero on a trip Times Square to enjoy some elaborate, Texas-sized cocktails. Seth is known for conducting hilarious day-drinking interviews on his show, but these ridiculous beverages will put his tolerance to the test. Guest: Seth Meyers.
第 15 集 COULDA BEEN A HERO
播出时间：2022年6月24日
Desus Nice and The Kid Mero go in on the news and cultural stories from the past week. Plus, they sit down for a conversation with New York Yankees legend Derek Jeter covering everything from his most memorable moments on the field to the specific things he used to whisper to opposing teams' first basemen. Then, Desus and Mero want to help their office's floundering softball team turn their season around, so they ask football analyst Mina Kimes to help break down some game footage. Illustrious guest: Derek Jeter.
