第 3 季 共 13 集
播出时间：2007年9月18日
第 1 集 Orientación
播出时间：2007年9月18日
Now locked up in a Panamanian prison known as Sona, Michael, T-Bag, Bellick, and Mahone try to find a way out. Much to their devastation, they soon find out that the prison has been abandoned by the authorities because of the immense threat from the vile inmates. Michael seeks for an inmate named Whistler in the prison sewers. As Lincoln is puzzled by Sara's sudden disappearance, he learns that LJ has gotten into some trouble. He also tries to recover the 5 million dollars.
第 2 集 Fire/Water
播出时间：2007年9月25日
Michael and Mahone try to lure Whistler out of his hiding place. T-Bag gains some upward momentum in the prison hierarchy as the water supply is running low. Lincoln meets familiar and not so familiar faces on his quest to free Michael.
第 3 集 Call Waiting
播出时间：2007年10月2日
Whistler tells the truth to Michael. Michael tries to get in touch with Sara but the only phone is in Lechero's quarters, so he has to rely on T-Bag's help. Mahone battles his addiction. Bellick steps on some toes.
第 4 集 Good Fences
播出时间：2007年10月9日
After taking delivery of a package from The Company, Lincoln realizes that they are deadly serious. Michael's new break out plan relies on electricity. Haywire is back from the dead, haunting disoriented Mahone. Bellick and T-Bag get special attention from Lechero.
第 5 集 Interference
播出时间：2007年10月23日
A new inmate named Tyge is brought to Sona. After he seemingly recognizes Whistler, Michael's doubts arise. T-Bag enters a new area of commerce.Lincoln goes to the seaside with Sofia. Sucre takes over the side-business of his predecessor.
第 6 集 Photo Finish
播出时间：2007年11月6日
Michael threatens to cancel the escape plan unless he sees a proof that Sarah is still alive. Whistler is accused of murdering an inmate and it is up to Michael to prove his innocence and save his life. Lincoln and Sofia help in monitoring the morning guards. Mahone may have another way to get out of Sona.
第 7 集 Vamonos
播出时间：2007年11月6日
Everything goes wrong for Michael as he tries to create a diversion.<br />
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Lincoln tries to outsmart Susan who has his son. Sucre offers his assistance to Lincoln.
第 8 集 Bang and Burn
播出时间：2007年11月13日
Susan jeopardizes Michael's life as she puts her own escape plan into motion. Whistler's past catches up to his girlfriend.The Company goes after Lincoln and Sucre. Justice prevails for Mahone. And Lechero sheds light into an empty tunnel.
第 9 集 Boxed In
播出时间：2008年1月15日
The Panamanian Army arranges Michael to get a taste of solitary. T-Bag reserves a spot in the escape. Bellick's life turns into an uphill battle. Susan traps Sucre.
第 10 集 Dirt Nap
播出时间：2008年1月22日
Lechero's demotion devastates Michael's breakout plan as Sammy takes reigns at Sona. T-Bag forces Bellick to fight in a fight where the odds are stacked heavily against him. Lincoln and Sucre have some surprise fireworks set for Susan.
第 11 集 Under and Out
播出时间：2008年2月5日
Michael's escape may be in jeopardy because of heavy rain. T-Bag and Lechero join forces, while Bellick hopes to do the same with Mahone.
第 12 集 Hell or High Water
播出时间：2008年2月12日
Michael, Whistler, and Mahone make their break from Sona. But Mahone seems like the odd man out along the way.
第 13 集 The Art of the Deal
播出时间：2008年2月19日
Michael and Lincoln are left with no choice but to hand Whistler over in exchange to save LJ and Sofia. A familiar face enters Sona while another inmate leaves.
