第 4 季 共 10 集
播出时间：2001年4月15日
第 1 集 Him Diddle Riddle
播出时间：2001年4月15日
Him has given the girls a set of nine riddles to solve in a time limit. The various tasks test both the girls' physical and mental faculties. However, if they fail to complete them all on time, Him promises them that "the Professor will pay".
第 2 集 Film Flam
播出时间：2001年4月21日
A sleazy director comes to Townsville to make a movie about the Powerpuff Girls.
第 3 集 All Chalked Up
播出时间：2001年4月28日
Buttercup smashes Bubbles's chalk when her drawings cover the playground's blacktop. An angry Bubbles is given magic chalk by Him (disguised as a butterfly) and encouraged to express her anger in her drawings.
第 4 集 Get Back Jojo
播出时间：2001年5月5日
It's career day at Pokey Oaks and the Professor comes with a time machine and explains how he got into science and created the Powerpuff Girls.
第 5 集 Members Only
播出时间：2001年5月26日
The girls try to join the superhero organization, the Justice Friends, but they must prove themselves to do so by tests of strength, speed, and smarts. But the only flaw about the organization is it doesn't allow "little girls" into the group and it's centered around men. However, when an enemy attacks the organization, the girls must come to their rescue.
第 6 集 Nano of the North
播出时间：2001年6月2日
Microscopic rain creatures eat away at Townsville.
第 7 集 Stray Bullet
播出时间：2001年6月9日
Alien invaders invade Townsville, and the Powerpuff Girls go to Mojo for help.
第 8 集 Forced Kin
播出时间：2001年6月23日
Alien invaders invade Townsville, and the Powerpuff Girls go to Mojo for help.
第 9 集 Knock It Off
播出时间：2001年7月14日
The Professor's old buddy and roommate from college Dick Hardly comes for a visit. When he sees the Powerpuff Girls he comes up with a scheme to make more of them and sell them as a security system.
第 10 集 Superfriends
播出时间：2002年5月19日
A new neighbor named Robin tries to make friends with the Powerpuff Girls, but its hard when they have to save the day all the time. Robin gets sad and makes a new friend: Princess Morebucks.
