第 6 季 共 18 集
播出时间：2004年6月26日
第 1 集 Little Miss Interprets
播出时间：2004年6月26日
When the Girls hear the Professor trying to make something out of sugar, spice, and everything nice, they are sure he's trying to create new little girls.
第 2 集 Night Mayor
播出时间：2004年6月26日
The Mayor keeps having the same dream over and over again, but he never sees the end. Now it's up Girls to go into the Mayor's head and solve this mystery.
第 3 集 Custody Battle
播出时间：2004年7月3日
When Mojo discovers that the Rowdyruff Boys have returned, he competes with Him to determine who's the more evil father.
第 4 集 City of Nutsville
播出时间：2004年7月3日
One day during a picnic Bubbles get stung in her mouth by a bee. After a visit by the doctor she is forbidden to speak for a week. Suddenly when all the squirrels in Townsville get mad, Blossom and Buttercup are unable to do anything without Bubbles special ability. Now it's up to Bubbles and Bullet to stop this crime.
第 5 集 Aspirations
播出时间：2004年7月10日
The Ganggreen Gang is committing brilliant crimes for Sedusa so she can get her revenge on the girls for making her bald.
第 6 集 That's Not My Baby
播出时间：2004年7月17日
The girls rescue a baby from a monster and are forced to care for it when they can't find its mother.
第 7 集 Simian Says
播出时间：2004年7月17日
Mojo takes over as the narrator. He commands the girls to do what he wants until it's revealed in the end what happened to the narrator.
第 8 集 Sun Scream
播出时间：2004年7月24日
The girls get bad sunburns.
第 9 集 City of Frownsville
播出时间：2004年7月24日
Lou Gubrious sets a crying ray on Townsville.
第 10 集 West In Pieces
播出时间：2004年7月31日
Professor Utomium sends the Steamypuff Girls to save the western town of Townsville from Mojo the Kid.
第 11 集 Crazy Mixed Up Puffs
播出时间：2004年8月21日
The Powerpuff Girls must literally work as one to try and stop Mojo Jojo from destroying Townsville.
第 12 集 Mizzen In Action
播出时间：2004年8月21日
Captain Crack McGraigen and his crew are tossed forward in time.
第 13 集 Roughing It Up
播出时间：2004年8月28日
The Powerpuff Girls and the Professor set on an old-fashioned vacation to the Townsville Swamp. Trouble is, Fuzzy and his nephews are there too.
第 14 集 What's the Big Idea?
播出时间：2004年8月28日
Twenty stories tall, The Powerpuff Girls spell disaster for Townsville when they delicately try to stop Mojo Jojo from taking over.
第 15 集 Nuthin' Special
播出时间：2005年3月26日
Buttercup feels left out when she realizes that she doesn't have any special powers like her sisters.
第 16 集 Neighbor Hood
播出时间：2005年3月26日
When a TV show convinces kids to send in money to enter a special contest, Bubbles and the rest of the kids in the neighbor hood raise money to enter it.
第 17 集 I See a Funny Cartoon in Your Future
播出时间：2005年3月26日
A medium named Madame Argentina, and her side-kick, Fred the duck (he really is a duck) attempt to steal money from Townsville's citizens by offering to contact a dead relative for them.
第 18 集 Octi Gone
播出时间：2005年3月26日
Professor Utonium is hosting a party for all the rich and famous people in Townsville, so Bubbles makes sure that she is the most beautiful of the girls by continually grooming herself. While doing this, she notices one of Octi's legs poking out from under the girls' bed, so she goes to pick him up to find that all that's there is one of Octi's legs! After waking up from the shock, she vows to exact revenge on the person who 'killed' Octi.
