第 2 季 共 26 集
播出时间：1999年6月26日
第 1 集 Stuck Up, Up and Away
播出时间：1999年6月26日
New student Princess Morebucks comes to Pokey Oaks kindergarten and after seeing The Powerpuff Girls in action she decides to become one.
第 2 集 Schoolhouse Rocked
播出时间：1999年6月26日
After being arrested by a truant officer(school policeman) the Gang Green Gang goes back to kindergarten and invades Pokey Oaks with tricks up their sleeves.
第 3 集 Collect Her
播出时间：1999年8月7日
Nerd boy Lenny Baxter has every single Powerpuff merchandise on the entire planet and now he decides to collect The Powerpuff Girls.
第 4 集 Supper Villain
播出时间：1999年8月7日
Next door neighbor Harold Smith can't stand the Powerpuff Girls so he creates a super villain identity to beat the Powerpuff Girls.
第 5 集 Birthday Bash
播出时间：1999年8月21日
The Professor throws the girls' a birthday party, but when every villain finds out about it they try to ruin the party.
第 6 集 Too Pooped To Puff
播出时间：1999年8月21日
The citizens of Townsville take advantage of the Powerpuff Girls and the girls' go out on a strike.
第 7 集 Beat Your Greens
播出时间：1999年9月11日
Alien broccoloids infect the broccoli of Townsville and now it's up to all the kids in Townsville(including the Powerpuff Girls) to defeat them.
第 8 集 Down n' Dirty
播出时间：1999年9月11日
Buttercup loves to fight monsters but taking a bath gets in the way, so to continue fighting monsters she doesn't take a bath for 3 days.
第 9 集 Dream Scheme
播出时间：1999年9月25日
Putting everyone in the world asleep can be a hard job so to make it easier the Sandman puts the world to sleep forever.
第 10 集 You Snooze You Lose
播出时间：1999年9月25日
Mojo Jojo creates the perfect plan to destroying The Powerpuff Girls ever, but because of an open window in his home Mojo's plan's fall into the Amoeba Boys' hands.
第 11 集 Slave the Day
播出时间：1999年10月9日
Big Billy from the Gang Green Gang gets saved from the train tracks by The Powerpuff Girls. Now he becomes their slave for life.
第 12 集 Los Dos Mojos
播出时间：1999年10月9日
Bubbles gets hit on the head by Mojo and gets amnesia.
第 13 集 A Very Special Blossom
播出时间：1999年11月27日
Blossom steals a set of $2000 golf clubs for Father's Day for the Professor.
第 14 集 Daylight Savings
播出时间：1999年11月27日
The Powerpuff Girls save the day before and after their bedtime, and by the time they're at school they always sleep in class. Annoyed by this Ms. Keane talks to the Professor and he gives them a curfew.
第 15 集 Mo Job
播出时间：2000年2月14日
Princess Morebucks hires Mojo Jojo to think up a brilliant plan to gain the Powerpuff's powers and destroy the Powerpuff Girls along with it.
第 16 集 Pet Feud
播出时间：2000年2月14日
The Professor creates a pet for the girls' that can only be fed once!
第 17 集 Imaginary Fiend
播出时间：2000年3月18日
A new kid at Pokey Oaks named Mike Believe is very unpopular with his classmates, so he creates an imaginary friend for himself who turns out to be an imaginary fiend.
第 18 集 Cootie Gras
播出时间：2000年3月18日
Harry Pitt has the cooties and everyone in Pokey Oaks are avoiding him including the Powerpuff Girls.
第 19 集 The Powerpuff Girls Best Rainy Day Adventure Ever
播出时间：2000年4月29日
A rainy day in Townsville becomes boring for the citizens of Townsville, so the Powerpuff Girls make the best out a terrible rainy day.
第 20 集 Just Desserts
播出时间：2000年4月29日
Harold Smith finally gets paroled out of jail, and when he comes back to his adoring family they end up hating the Powerpuff Girls just as much as he does. Equipped with all sorts of high tech weapons the Smith's take their revenge out on the Utonium family.
第 21 集 Twisted Sister
播出时间：2000年5月27日
To pooped out from fighting crime all the time the Powerpuff Girls create a 4th Powerpuff Girl named Bunny.
第 22 集 Cover Up
播出时间：2000年5月27日
The tough Buttercup's secret is revealed when her sister's learn that Buttercup's source of power is her little green blankie.
第 23 集 Speed Demon
播出时间：2000年6月3日
After a long week of school the girls' get a long weekend to go to the Bahamas. Buttercup dares them to race home and when they do they travel 50 years into the future.
第 24 集 Mojo Jonesin'
播出时间：2000年6月3日
The kids at Pokey Oaks really like The Powerpuff Girls, so Mojo gives a few kids a dose of chemical X.
第 25 集 Something's A Ms.
播出时间：2000年7月1日
Ms. Bellum seduces the Mayor to get some time off, but when something seems a miss the Powerpuff Girls investigate the situation.
第 26 集 Slumbering with the Enemy
播出时间：2000年7月1日
The Powerpuff Girls throw a slumber party and invites every girl in their school to come. By the time they give their invitation out to the last girl Mojo steals it and comes to the party dressed up as Mojesha.
